CORRECTION OF CEREBROSPINAL FLUID PROTEIN IN INFANTS WITH TRAUMATIC LUMBAR PUNCTURES

• Type of Material: Article
• Authors: Todd W. Lyons, Boston Childrens Hospital; Andrea T. Cruz, Baylor College of Medicine; Stephen B. Freedman, University of Calgary; Joseph L. Arms, Childrens Minnesota; Paul L. Aronson, Yale School of Medicine; Alesia Fleming, Emory University; Dina M. Kulik, Hospital for Sick Children; Prashant Mahajan, University of Michigan; Rakesh D. Mistry, Children's Hospital Colorado; Christopher M. Pruitt, University of Alabama Birmingham; Amy D. Thompson, Nemours/Alfred I. duPont Hospital for Children; Lise Nigrovic, Boston Childrens Hospital
• Language: English
• Date: 2017-10-01
• Publisher: Lippincott, Williams & Wilkins
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2017 Wolters Kluwer Health, Inc. All rights reserved.
• Final Published Version (URL): http://dx.doi.org/10.1097/INF.0000000000001634
• Title of Journal or Parent Work: Pediatric Infectious Disease Journal
• ISSN: 0891-3668
• Volume: 36
• Issue: 10
• Start Page: 1006
• End Page: +
• Grant/Funding Information: Dr. Lyons was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (National Institutes of Health) T32 Training Grant (5T32HD040128-12).; The network data center managed by Baylor College of Medicine was supported by the Section of Emergency Medicine, American Academy of Pediatrics (AAP) and Baylor College of Medicine.; Dr. Freedman is supported by the Alberta Children’s Hospital Foundation Professorship in Child Health and Wellness.; Paul L. Aronson is supported by CTSA grant number KL2 TR001862 from the National Center for Advancing Translational Science (NCATS), a component of the National Institutes of Health (NIH).
• Keywords: Infectious Diseases; Immunology; YOUNG INFANTS; Pediatrics; Life Sciences & Biomedicine; infants; Science & Technology; cerebrospinal fluid; RISK; RED-BLOOD-CELLS; CHILDREN; AGE; bacterial meningitis; protein
• Research Categories: Health Sciences, Immunology

Abstract

In our multicenter cohort of infants ≤60 days of age, we identified 2646 infants with a traumatic lumbar puncture, of which 31 (1.2%) had bacterial meningitis. For every 1000 cerebrospinal fluid red blood cells/mm3, cerebrospinal (cerebrospinal fluid) protein increased 1.1 mg/dL (95% confidence interval: 1.0-1.2 mg/dL).