MOR23 promotes muscle regeneration and regulates cell adhesion and migration

• Type of Material: Article
• Authors: Christine A. Griffin, Emory University; Kimberly A. Kafadar, Emory University; Grace K Pavlath, Emory University
• Language: English
• Date: 2009-11-17
• Publisher: Elsevier (Cell Press)
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2009, Elsevier
• License: Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1016/j.devcel.2009.09.004
• Title of Journal or Parent Work: Developmental Cell
• ISSN: 1534-5807
• Volume: 17
• Issue: 5
• Start Page: 649
• End Page: 661
• Grant/Funding Information: KAK was supported by an MDA Development grant.; CAG was supported by National Institutes of Health training grant T32-GM08367.; GKP was supported by grants AR-047314, AR-051372, and AR-052730 from the National Institutes of Health and the Muscular Dystrophy Association.
• Keywords: Olfr16; migration; myofiber splitting; MOR23; adhesion; myofiber branching; regeneration; fusion; olfactory receptor
• Research Categories: Health Sciences, Pharmacology; Chemistry, Biochemistry

Abstract

Odorant receptors (ORs) in the olfactory epithelium bind to volatile small molecules leading to the perception of smell. ORs are expressed in many tissues but their functions are largely unknown. We show multiple ORs display distinct mRNA expression patterns during myogenesis in vitro and muscle regeneration in vivo. Mouse OR23 (MOR23) expression is induced during muscle regeneration when muscle cells are extensively fusing and plays a key role in regulating migration and adhesion of muscle cells in vitro, two processes common during tissue repair. A soluble ligand for MOR23 is secreted by muscle cells in vitro and muscle tissue in vivo. MOR23 is necessary for proper skeletal muscle regeneration as loss of MOR23 leads to increased myofiber branching, commonly associated with muscular dystrophy. Together these data identify a functional role for an OR outside of the nose and suggest a larger role for ORs during tissue repair.