Contraceptive methods and fertility testing in young adult survivors of childhood cancer

• Type of Material: Article
• Authors: Brooke Cherven, Emory University; Lauren F. Quast, Emory University; James Klosky, Emory University; Cynthia A. Gerhardt, The Ohio State University; Katja Baust, University Hospital Bonn; Gabriele Galaminus, University of Hospital Bonn; Peter Kaatsch, University Medical Center Mainz; Mariët Hagedoorn, University Medical Center Groningen; Marrit A. Tuinman, University Medical Center Groningen; Vicky Lehmann, University of Amsterdam
• Language: English
• Date: 2023-08-16
• Publisher: Springer
• Publication Version: Final Published Version
• Copyright Statement: © The Author(s) 2023
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): https://doi.org/10.1007%2Fs10815-023-02908-7
• Title of Journal or Parent Work: Journal of Assisted Reproduction and Genetics
• Volume: 40
• Issue: 10
• Start Page: 2391
• End Page: 2400
• Grant/Funding Information: This study was partially funded by a grant from the German Cancer Aid (#70112102; Calaminus, Kaatsch, Langer). Brooke Cherven is supported by the National Institute of Nursing Research of the National Institutes of Health under Award Number K23NR020037.
• Keywords: oncofertility; survivorship; Contraception; young adult; gertility testing; Childhood cancer
• Research Categories: Health Sciences, Obstetrics and Gynecology; Health Sciences, Oncology

Abstract

Purpose Reproductive health is important, but often neglected in cancer survivorship care. This study explored contraceptive use and factors associated with fertility testing among young adult survivors of childhood cancer in Germany. Methods Young adult survivors of childhood cancer were identified through the German Childhood Cancer Registry and completed a mailed survey. Survivors were queried regarding contraceptive use, reproductive goals, uncertainty about fertility, and completion or interest in fertility testing. Multivariable stepwise logistic regression models were used to calculate Odds Ratios (OR) and 95% confidence intervals (CI) as a means of identifying factors associated with completion of and interest in fertility testing. Results Survivors (N = 472; 57.8% female; aged 23.3 ± 1.5 years, and 14.9 ± 5.0 years from diagnosis), reported high rates of contraceptive use, including 61.2% using a single method, 30.6% dual methods, and 8.1% no/less effective methods. Few survivors had completed fertility testing (13.0%), although 58.8% were interested. Having been diagnosed during adolescence (OR = 2.66, 95%CI: 1.39–5.09), greater uncertainty about fertility (OR = 1.16, 95%CI: 1.03–1.31), and use of dual contraceptive methods (OR = 1.94, 95%CI: 1.02–3.69) were associated with having completed fertility testing. Factors associated with interest in fertility testing included goals of wanting to have children (OR = 7.76, 95%CI: 3.01–20.04) and greater uncertainty about fertility (OR = 1.19 95%CI: 1.06–1.33). Conclusion In this sample of young adults who survived childhood cancer, most reported contraceptive use. Few survivors had completed fertility testing, although more than half were interested. Interventions are needed to address potential barriers to fertility testing and help survivors manage fertility-related uncertainty.