Computational fluid dynamics applied to virtually deployed drug-eluting coronary bioresorbable scaffolds: Clinical translations derived from a proof-of-concept.

• Type of Material: Article
• Authors: Bill D. Gogas, Emory University; Boyi Yang, Emory University; Tiziano Passerini, Emory University; Alessandro Veneziani, Emory University; Marina Piccinelli, Emory University; Gaetano Esposito, Emory University; Emad Rasoul-Arzrumly, Emory University; Mosaab Awad, Emory University; Girum Mekonnen, Emory University; Olivia Y. Hung, Emory University; Beth Holloway, Emory University; Michael McDaniel, Emory University; Don P Giddens, Emory University; Spencer King, Emory University; Habib Samady, Emory University
• Language: English
• Date: 2014
• Publisher: Bloomsbury Qatar Foundation Journals
• Publication Version: Final Published Version
• Copyright Statement: © 2014 Gogas, Yang, Passerini, Veneziani, Piccinelli, Esposito, Rasoul-Arzrumly, Awad, Mekonnen, Hung, Holloway, McDaniel, Giddens, King III, Samady, licensee Bloomsbury Qatar Foundation Journals.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.5339/gcsp.2014.56
• Title of Journal or Parent Work: Global Cardiology Science And Practice
• ISSN: 2305-7823
• Volume: 2014
• Issue: 4
• Start Page: 428
• End Page: 436
• Keywords: computational fluid dynamics; virtual modeling; bioresorbable scaffolds
• Research Categories: Mathematics; Health Sciences, General; Health Sciences, Radiology

Abstract

Background: Three-dimensional design simulations of coronary metallic stents utilizing mathematical and computational algorithms have emerged as important tools for understanding biomechanical stent properties, predicting the interaction of the implanted platform with the adjacent tissue, and informing stent design enhancements. Herein, we demonstrate the hemodynamic implications following virtual implantation of bioresorbable scaffolds using finite element methods and advanced computational fluid dynamics (CFD) simulations to visualize the device-flow interaction immediately after implantation and following scaffold resorption over time. Methods and Results: CFD simulations with time averaged wall shear stress (WSS) quantification following virtual bioresorbable scaffold deployment in idealized straight and curved geometries were performed. WSS was calculated at the inflow, endoluminal surface (top surface of the strut), and outflow of each strut surface post-procedure (stage I) and at a time point when 33% of scaffold resorption has occurred (stage II). The average WSS at stage I over the inflow and outflow surfaces was 3.2 and 3.1 dynes/cm2 respectively and 87.5 dynes/cm2 over endoluminal strut surface in the straight vessel. From stage I to stage II, WSS increased by 100% and 142% over the inflow and outflow surfaces, respectively, and decreased by 27% over the endoluminal strut surface. In a curved vessel, WSS change became more evident in the inner curvature with an increase of 63% over the inflow and 66% over the outflow strut surfaces. Similar analysis at the proximal and distal edges demonstrated a large increase of 486% at the lateral outflow surface of the proximal scaffold edge. Conclusions: The implementation of CFD simulations over virtually deployed bioresorbable scaffolds demonstrates the transient nature of device/flow interactions as the bioresorption process progresses over time. Such hemodynamic device modeling is expected to guide future bioresorbable scaffold design.