Redox biology: Interface of the exposome with the proteome, epigenome and genome

• Type of Material: Article
• Authors: Young-Mi Kanggo, Emory University; Dean P Jones, Emory University
• Language: English
• Date: 2014-01-10
• Publisher: Elsevier
• Publication Version: Final Published Version
• Copyright Statement: © 2014 The Authors
• License: Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1016/j.redox.2013.12.032
• Title of Journal or Parent Work: Redox Biology
• Volume: 2
• Start Page: 358
• End Page: 360
• Grant/Funding Information: This work was supported by NIH grants ES009047, HL113451, AG38746 and ES019116.
• Keywords: Redox signaling; Oxidative stress; Life cycle; Environmental exposures; Personalized medicine
• Research Categories: Health Sciences, Medicine and Surgery

Abstract

The exposome is the cumulative measure of environmental influences and associated biological responses throughout lifespan, including exposures from the environment, diet, behavior and endogenous processes. Much of the direct interaction of an individual's exposome involves redox biology as the body responds to environmental, dietary and behavioral risk factors of disease. The present commentary addresses this critical interface and the need for redox biologists to lead development of concepts and strategies to sequence the exposome.