Robustness and innovation along the endocytic route: Lessons from darkness

• Type of Material: Article
• Authors: Kaela S. Singleton, Emory University; Victor Faundez, Emory University
• Language: English
• Date: 2021-07-05
• Publisher: ROCKEFELLER UNIV PRESS
• Publication Version: Final Published Version
• Copyright Statement: © 2021 Singleton and Faundez
• License: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1083/jcb.202105030
• Title of Journal or Parent Work: JOURNAL OF CELL BIOLOGY
• Volume: 220
• Issue: 7
• Grant/Funding Information: This work was supported by grants from the National Institutes of Health (1RF1AG060285 to V. Faundez and 4K00NS108539 to K.S. Singleton).
• Keywords: Life Sciences & Biomedicine; Science & Technology; Cell Biology
• Research Categories: Biology, Cell

Abstract

What mechanisms ensure the loading of a SNARE into a nascent carrier? In this issue, Bowman et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202005173) describe an unprecedented mechanism where two sorting complexes, AP-3 and BLOC-1, the latter bound to syntaxin 13, work as a fail-safe to recognize sorting signals in VAMP7, a membrane protein required for fusion to melanosomes. Their observations define one of the first examples of distributed robustness in membrane traffic mechanisms.