Publication

Association between dimensions of trauma-related psychopathology and asthma in trauma-exposed women

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Last modified
  • 06/25/2025
Type of Material
Authors
    Esther R-H Lin, Emory UniversityAlyssa Roeckner, Emory UniversityNegar Fani, Emory UniversityNatalie Ann Merrill, Emory UniversityCharles Gillespie, Emory UniversityTimothy D. Ely, Emory UniversityBekh Bradley-Davino, Emory UniversityVasiliki Michopoulos, Emory UniversityAbigail Powers, Emory UniversityTanja Jovanovic, Wayne State UniversityJennifer S. Stevens, Emory University
Language
  • English
Date
  • 2023-10-31
Publisher
  • Frontiers
Publication Version
Copyright Statement
  • © 2023 Lin, Roeckner, Fani, Merrill, Gillespie, Ely, Bradley, Michopoulos, Powers, Jovanovic and Stevens.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 17
Start Page
  • 1268877
Grant/Funding Information
  • The study was supported by National Institute of Mental Health, Grant/Award Numbers: MH098212, MH071537, MH101380, MH101976, MH096764, MH117009, and MH128244, National Center for Advancing Translational Sciences, Grant/Award Number: UL1TR000454, and Eunice Kennedy Shriver National Institute of Child Health and Human Development, Grant/Award Number: HD085850.
Supplemental Material (URL)
Abstract
  • Introduction Exposure to traumatic events and stressful life experiences are associated with a wide range of adverse mental and physical health outcomes. Studies have found post-traumatic stress disorder (PTSD), depression, and anxiety sensitivity occurrence to be common in addition to inflammatory diseases like asthma, especially in women. Moreover, overlapping neurobiological mechanisms have been linked to both PTSD and asthma. Methods In the current study, n = 508 women reported on presence of lifetime asthma diagnosis and symptoms of trauma-related psychopathology including PTSD and depression. A separate group of female participants (n = 64) reported on asthma, PTSD, depression and anxiety sensitivity, and underwent functional MRI scans during a fearful faces task, and their anterior insula responses were analyzed. Results Overall, PTSD and depression severity were significantly higher in those with asthma versus those without asthma. There was a positive association between anterior insula response to social threat cues and depression symptoms only among individuals without a lifetime presence of asthma. Discussion These findings provide continued evidence on the interactions between stress, neural mechanisms involved in interoception and salience detection, and trauma-related psychopathology.
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Keywords
Research Categories
  • Psychology, Clinical
  • Biology, Neuroscience

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