Phosphoinositide 3-kinase enhancer (PIKE) in the brain: is it simply a phosphoinositide 3-kinase/Akt enhancer?

• Type of Material: Article
• Authors: Chi Bun Chan, Emory University; Keqiang Ye, Emory University
• Language: English
• Date: 2012-01-26
• Publisher: De Gruyter
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © by Walter de Gruyter
• Final Published Version (URL): http://www.degruyter.com/view/j/revneuro.2012.23.issue-2/revneuro-2011-0066/revneuro-2011-0066.xml;jsessionid=C25C3820E1971CA0BE38F3E115F946DB
• Title of Journal or Parent Work: Reviews in the Neurosciences
• ISSN: 0334-1763
• Volume: 23
• Issue: 2
• Start Page: 153
• End Page: 161
• Grant/Funding Information: This work is supported by the National Institutes of Health grant no. RO1 CA127119 (Keqiang Ye) and the Emory University (University Research Committee) grant No. 00016337 (Chi Bun Chan).
• Keywords: GTPase; PI3K; neuron; PIKE; Akt
• Research Categories: Health Sciences, Pathology; Health Sciences, Medicine and Surgery

Abstract

Since its discovery in 2000, phosphoinositide 3-kinase enhancer (PIKE) has been recognized as a class of GTPase that controls the enzymatic activities of phosphoinositide 3-kinase (PI3K) and Akt in the central nervous system (CNS). However, recent studies suggest that PIKEs are not only enhancers to PI3K/Akt but also modulators to other kinases including insulin receptor tyrosine kinase and focal adhesion kinases. Moreover, they regulate transcription factors such as signal transducer and activator of transcription and nuclear factor κB. Indeed, PIKE proteins participate in multiple cellular processes including control of cell survival, brain development, memory formation, gene transcription, and metabolism. In this review, we have summarized the functions of PIKE proteins in CNS and discussed their potential implications in various neurological disorders.