Reply to S.A. Upadhyaya: Relevance of the Type and Timing of Radiation Therapy to the Outcomes Reported in the ACNS0333 Trial for Atypical Teratoid/Rhabdoid Tumors

• Type of Material: Article
• Authors: Alyssa T. Reddy, University of California San Francisco; Mark D. Krailo, University of Southern California; Allen B. Buxton, Children's Oncology Group; Douglas R. Strother, University of Calgary; Annie Huang, Hospital for Sick Children; Tianni Zhou, California State University Long Beach; Alexander R. Judkins, University of Southern California; Peter C. Burger, Johns Hopkins University; Ian F. Pollack, University of Pittsburgh; Chris Williams-Hughes, Children's Oncology Group; Maryam Fouladi, Cincinnati Children's Hospital Medical Center; Ben Ho, Hospital for Sick Children; Claire Mazewski, Emory University; Victor A. Lewis, University of Calgary; Louis-Gilbert Vezina, George Washington University; Timory N. Booth, University of Texas Southwestern; Anita Mahajan, Mayo Clinic
• Language: English
• Date: 2020-10-01
• Publisher: AMER SOC CLINICAL ONCOLOGY
• Publication Version: Final Published Version
• Copyright Statement: © 2020 by American Society of Clinical Oncology
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1200/JCO.20.01573
• Title of Journal or Parent Work: JOURNAL OF CLINICAL ONCOLOGY
• Volume: 38
• Issue: 28
• Start Page: 3353
• End Page: 3354
• Keywords: Science & Technology; Life Sciences & Biomedicine; Oncology
• Research Categories: Health Sciences, Oncology

Abstract

We thank Upadhyaya for his comments on our article, Reddy et al, and his questions regarding the relevance of craniospinal irradiation (CSI) to the outcomes reported. ACNS0333 (ClinicalTrials.gov identifier: NCT00653068) was a nonrandomized trial that prescribed intensive chemotherapy and radiation therapy (RT), and the results were analyzed according to the intent-to-treat principle. The study was designed to identify whether the therapeutic regimen increased survival. ACNS0333 was powered for the primary analysis, namely the comparison of risk of an event-free survival (EFS) for patients younger than age 36 months at diagnosis with cohorts of patients from historical cooperative groups. The examination of other variables, including RT, was exploratory with no expectation of demonstrating conventional statistical significance. The goal of that article was to present primary and secondary objective results.