Normalized measures and patient characteristics to identify undernutrition in infants and young children treated for cancer

• Type of Material: Article
• Authors: Daniel V Runco, Indiana University School of Medicine; Karen Wasilewski-Masker, Emory University; Courtney E McCracken, Emory University School of Medicine; Martha Wetzel, Emory University School of Medicine; Claire Mazewski, Emory University; Briana Patterson, Emory University; Ann Mertens, Emory University
• Language: English
• Date: 2020-08-01
• Publisher: Emory University Libraries
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2020 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.clnesp.2020.05.005
• Title of Journal or Parent Work: Clinical Nutrition ESPEN
• Volume: 38
• Start Page: 185
• End Page: 191
• Keywords: Humans; Neoplasm Recurrence, Local; Retrospective Studies; Child; Infant; Malnutrition; Cancer; Weight Loss; Nutrition; Parenteral Nutrition; Weight loss; Child, Preschool; Anthropometric measures; Pediatric oncology; Adolescent

Abstract

Background: Various measures and definitions for undernutrition are used in pediatrics. Younger children treated for cancer are at high risk, but lack well-defined risk-based screening and intervention. Methods: A retrospective study collected weight longitudinally for patients less than three years-old over two years after initiating cancer treatment. We included those diagnosed 2007–2015 at a large pediatric cancer center. Exclusion criteria included treatment starting outside our system, secondary or relapsed malignancy, or incomplete information. A decrease ≥1 in weight-for-age or weight-for-height z-score signified clinically significant weight loss. Univariate and multivariate models assessed hazards for developing first episode of clinically significant weight loss. Results: Of 372 patients, only 24.6% of patients lost 10% of weight, but 58.6% lost weight-for-age z-score ≥1 and 64.8% lost ≥1 weight-for-height z-score within two years of treatment initiation. Patients who lost weight were younger (median age 15 vs. 24 months, p < 0.001). Compared to patients diagnosed in the first year of life, those diagnosed 24–35 months were less likely to lose weight (HR 0.62, p < 0.001) and lost weight later (median time to weight loss 144 vs. 35 days). Higher treatment intensity increased weight loss risk (HR 2.30, p < 0.001) and decreased time to weight loss (35 vs. 154 days). No differences were found based on sex, diagnosis, enteral or parenteral nutrition, gastroenterology consults, or intensive care admissions. Conclusions: Using normalized z-scores is more sensitive for identifying weight loss. Younger children are more likely to lose weight with higher intensity cancer therapy. Patient and treatment specific information should be used in risk stratifying weight loss screening and nutritional interventions.