Publication

Neurological and psychiatric sequelae of developmental exposure to antiepileptic drugs

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Last modified
  • 02/20/2025
Type of Material
Authors
    Evan Gedzelman, Emory UniversityKim J Meador, Emory University
Language
  • English
Date
  • 2012-12-27
Publisher
  • Frontiers Research Foundation
Publication Version
Copyright Statement
  • © 2012 Gedzelman and Meador
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1664-2295
Volume
  • 3
Issue
  • 182
Start Page
  • 1
End Page
  • 8
Grant/Funding Information
  • Dr. Meador reports receiving research support from the GlaxoSmithKline, EISAI Medical Research, Myriad Pharmaceuticals, Marinus Pharmaceuticals, NeuroPace, Pfizer, SAM Technology, Schwartz Biosciences, and UCB Pharma, the Epilepsy Foundation, and the NIH
Abstract
  • The neurons in the developing mammalian brain are susceptible to antiepileptic drug (AED) effects. It is known that later in life deficits in cognitive performance as well as psychiatric deficits can manifest after early AED exposure. The extent of these deficits will be addressed. This review will attempt to draw parallels between the existent animal models and human studies. Through analysis of these studies, important future research will be elucidated and possible new and emerging therapies will be discussed.
Author Notes
  • Correspondence: Evan R. Gedzelman and Kimford J. Meador, Department of Neurology, Emory University School of Medicine, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA. E-mail: evan.r.gedzelman@emory.edu; kimford.meador@emory.edu
Research Categories
  • Biology, Neuroscience

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