Modulation of CTCF insulator function by transcription of a non-coding RNA

• Type of Material: Article
• Authors: Chin-Tong Ong, Emory University; Victor Corces, Emory University
• Language: English
• Date: 2008-10
• Publisher: Elsevier (Cell Press)
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2008 Elsevier Inc. All rights reserved.
• License: Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported
• Final Published Version (URL): http://www.cell.com/developmental-cell/retrieve/pii/S153458070800395X
• Title of Journal or Parent Work: Developmental Cell
• ISSN: 1534-5807
• Volume: 15
• Issue: 4
• Start Page: 489
• End Page: 490
• Keywords: chromatin; transcription; CTCF; insulator
• Research Categories: Biology, Genetics

Abstract

CTCF plays diverse roles in the regulation of eukaryotic genes. A new study by Lefevre et al., 2008 reveals a novel mechanism in which non-coding RNA transcription and nucleosome repositioning evicts CTCF from a regulatory element, to facilitate induction of a nearby gene.