To Each Its Own: Linking the Biology and Epidemiology of NHL Subtypes

• Type of Material: Article
• Authors: Jean Louise Koff, Emory University; Dai Chihara, University of Texas; Anh Phan, Emory University; Loretta J. Nastoupil, University of Texas; Jessica N. Williams, Emory University; Christopher R Flowers, Emory University
• Language: English
• Date: 2015-09-01
• Publisher: Current Medicine Group
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2015, Springer Science+Business Media New York.
• Final Published Version (URL): http://dx.doi.org/10.1007/s11899-015-0267-0
• Title of Journal or Parent Work: Current Hematologic Malignancy Reports
• ISSN: 1558-8211
• Volume: 10
• Issue: 3
• Start Page: 244
• End Page: 255
• Grant/Funding Information: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.; This publication was supported in part by award number R21 CA158686 to Dr. Flowers.
• Keywords: B-CELL LYMPHOMA; CLASS SWITCH RECOMBINATION; Hematology; Life Sciences & Biomedicine; INTERLYMPH-CONSORTIUM; Non-Hodgkin lymphoma; GENOME-WIDE ASSOCIATION; Science & Technology; Biology; Oncology; Epidemiology; NHL subtypes; NON-HODGKIN-LYMPHOMA; UNITED-STATES; CHRONIC LYMPHOCYTIC-LEUKEMIA; Autoimmune disorders; POOLED ANALYSIS; HELICOBACTER-PYLORI INFECTION; FOLLICULAR LYMPHOMA
• Research Categories: Health Sciences, Oncology; Health Sciences, Epidemiology

Abstract

Non-Hodgkin lymphoma (NHL) constitutes a diverse group of more than 40 subtypes, each characterized by distinct biologic and clinical features. Until recently, pinpointing genetic and epidemiologic risk factors for individual subtypes has been limited by the relative rarity of each. However, several large pooled case-control studies have provided sufficient statistical power for detecting etiologic differences and commonalities between subtypes and thus yield new insight into their unique epidemiologic backgrounds. Here, we review the subtype-specific medical, lifestyle, and biologic components identified in these studies, which suggest that a complex interplay between host genetics, autoimmune disorders, modifiable risk factors, and occupation contributes to lymphomagenesis.