p39, the Primary Activator for Cyclin-dependent Kinase 5 (Cdk5) in Oligodendroglia, Is Essential for Oligodendroglia Differentiation and Myelin Repair

• Type of Material: Article
• Authors: Andrew N. Bankston, Emory University; Wenqi Li, Emory University; Hui Zhang, Emory University; Li Ku, Emory University; Guanglu Liu, Emory University; Filomena Papa, University of Kentucky; Lixia Zhao, Emory University; James A. Bibb, The University of Texas Southwestern; Franca Cambi, University of Kentucky; Seema K. Tiwari-Woodruff, University of California, Los Angeles; Yue Feng, Emory University
• Language: English
• Date: 2013-06-21
• Publisher: American Society for Biochemistry and Molecular Biology
• Publication Version: Final Published Version
• Copyright Statement: © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
• Final Published Version (URL): http://www.jbc.org/content/288/25/18047
• Title of Journal or Parent Work: Journal of Biological Chemistry
• ISSN: 0021-9258
• Volume: 288
• Issue: 25
• Start Page: 18047
• End Page: 18057
• Grant/Funding Information: Supported by National Institutes of Health Training Grant T32GM008602.; This work was supported, in whole or in part, by National Institutes of Health Grants NS053905 (to Y. F.), NS053905-03S2 (to F. C.), and MH083711, DA033485, and NS073855 (to J. A. B.). This work was also supported by National Multiple Sclerosis Society Grant NMSSRG 4010-A (to Y. F.) and an Emory University Research Committee grant (to Y. F.).; The FACS sorting facility at the University of Kentucky is supported in part by the National Institutes of Health Shared Instrument Program (S10 RR026827-01A1).
• Keywords: Cyclin-dependent Kinase 5 (Cdk5); Differentiation; Myelin; p39; Oligodendroglia; Neurons; Gene Regulation; Glia
• Research Categories: Health Sciences, General; Biology, Molecular; Chemistry, Biochemistry

Abstract

Background: Cyclin-dependent kinase 5 (Cdk5) is crucial for brain development. Results: In contrast to neurons that utilize p35 as the primary Cdk5 activator, oligodendroglia employ p39-dependent Cdk5 activation to advance differentiation and myelin repair. Conclusion: p39 is the primary Cdk5 activator in oligodendroglia, essential for oligodendroglia development. Significance: Our study revealed distinct mechanisms controlling Cdk5 activity in neurons and oligodendroglia.