NSDNA: a manually curated database of experimentally supported ncRNAs associated with nervous system diseases.

• Type of Material: Article
• Authors: Jianjian Wang, The Second Affiliated Hospital of Harbin Medical University; Yuze Cao, The Second Affiliated Hospital of Harbin Medical University; Huixue Zhang, The Second Affiliated Hospital of Harbin Medical University; Tianfeng Wang, The Second Affiliated Hospital of Harbin Medical University; Qinghua Tian, The Second Affiliated Hospital of Harbin Medical University; Xiaoyu Lu, The Second Affiliated Hospital of Harbin Medical University; Xiaoyan Lu, The Second Affiliated Hospital of Harbin Medical University; Xiaotong Kong, The Second Affiliated Hospital of Harbin Medical University; Zhaojun Liu, The Second Affiliated Hospital of Harbin Medical University; Xing Wang, The Second Affiliated Hospital of Harbin Medical University; Shuai Zhang, The Second Affiliated Hospital of Harbin Medical University; He-Ping Ma, Emory University; Shangwei Ning, Harbin Medical University; Lihua Wang, The Second Affiliated Hospital of Harbin Medical University
• Language: English
• Date: 2017-01-04
• Publisher: Oxford University Press (OUP)
• Publication Version: Final Published Version
• Copyright Statement: © The Author(s) 2016. For commercial re-use, please contact [e-mail].
• License: Creative Commons Attribution-NonCommercial 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1093/nar/gkw1038
• Title of Journal or Parent Work: Nucleic Acids Research
• ISSN: 0305-1048
• Volume: 45
• Issue: D1
• Start Page: D902
• End Page: D907
• Grant/Funding Information: National Natural Science Foundation of China [81371324, 81571166 and 31401090]; Specialized Research Fund for the Doctoral Program of Higher Education of China [20132307110008]; Foundation of Heilongjiang Medical Science Institute [201406]; Health and Family Planning Commission of Heilongjiang Province [2016-052 and 2016-072]. Funding for open access charge: National Natural Science Foundation of China [81371324, 81571166 and 31401090].
• Research Categories: Biology, Neuroscience; Biology, Bioinformatics; Health Sciences, General

Abstract

The Nervous System Disease NcRNAome Atlas (NSDNA) (http://www.bio-bigdata.net/nsdna/) is a manually curated database that provides comprehensive experimentally supported associations about nervous system diseases (NSDs) and noncoding RNAs (ncRNAs). NSDs represent a common group of disorders, some of which are characterized by high morbidity and disabilities. The pathogenesis of NSDs at the molecular level remains poorly understood. ncRNAs are a large family of functionally important RNA molecules. Increasing evidence shows that diverse ncRNAs play a critical role in various NSDs. Mining and summarizing NSD-ncRNA association data can help researchers discover useful information. Hence, we developed an NSDNA database that documents 24 713 associations between 142 NSDs and 8593 ncRNAs in 11 species, curated from more than 1300 articles. This database provides a user-friendly interface for browsing and searching and allows for data downloading flexibility. In addition, NSDNA offers a submission page for researchers to submit novel NSD-ncRNA associations. It represents an extremely useful and valuable resource for researchers who seek to understand the functions and molecular mechanisms of ncRNA involved in NSDs.