The Use of Functional Near-Infrared Spectroscopy to Differentiate Alcohol-Related Neurodevelopmental Impairment

• Type of Material: Article
• Authors: Catherine E. Barrett, Emory University; Julie Kable, Emory University; Teresa E. Madsen, Emory University; Chia-Chun Hsu, Emory University; Claire Coles, Emory University
• Language: English
• Date: 2019-01-01
• Publisher: ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2019, © 2019 Taylor & Francis.
• Final Published Version (URL): http://dx.doi.org/10.1080/87565641.2019.1567734
• Title of Journal or Parent Work: DEVELOPMENTAL NEUROPSYCHOLOGY
• Volume: 44
• Issue: 2
• Start Page: 203
• End Page: 219
• Grant/Funding Information: All or part of this work was done in conjunction with the Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD), which is funded by grants from the National Institute on Alcohol Abuse and Alcoholism (NIAAA).; This work was supported by a grant from the Spray Foundation and by a NIH Research Grant #U24AA014811 funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
• Keywords: SPATIAL WORKING-MEMORY; PREFRONTAL BRAIN ACTIVATION; ADHD CHILDREN; NEUROBEHAVIORAL PROFILE; Psychology; EXPOSURE; RESPONSE-INHIBITION; BOLD RESPONSE; Social Sciences; MAGNETIC-RESONANCE; Psychology, Experimental; SPECTRUM DISORDERS; Psychology, Developmental; EXECUTIVE FUNCTION
• Research Categories: Psychology, Experimental; Psychology, Developmental; Biology, Neuroscience

Abstract

Oxygenated (HBO) and deoxygenated hemoglobin (HBR) levels in the prefrontal cortex (PFC) were measured using functional near-infrared spectroscopy (fNIRS) to determine if PFC activity during a cognitive inhibition task distinguishes children with prenatal alcohol exposure (PAE, n = 26) from both typically developing controls (n = 19) and a contrast group of children with other neurobehavioral problems (n = 14). Despite showing evidence of increased PFC activity in the non-inhibitory condition relative to controls, children in the PAE group displayed reduced PFC HBO and increased HBR relative to both other groups in the inhibitory condition, suggesting reduced PFC activity but increased oxygen consumption without sufficient oxygen replacement.