Insulators and imprinting from flies to mammals

• Type of Material: Article
• Authors: Chunhui Hou, Emory University; Victor Corces, Emory University
• Language: English
• Date: 2010-07-30
• Publisher: BioMed Central
• Publication Version: Final Published Version
• Copyright Statement: ©2010 Hou and Corces; licensee BioMed Central Ltd.
• License: Creative Commons Attribution 2.0 Generic
• Title of Journal or Parent Work: BMC Biology
• Volume: 8
• Start Page: 104
• End Page: 104
• Grant/Funding Information: Work in the authors' laboratory is supported by Public Health Service Award GM35463 from the National Institutes of Health.
• Research Categories: Biology, General

Abstract

The nuclear factor CTCF has been shown to be necessary for the maintenance of genetic imprinting at the mammalian H19/Igf2 locus. MacDonald and colleagues now report in BMC Biology that the mechanisms responsible for maintaining the imprinted state in Drosophila may be evolutionarily conserved and that CTCF may also play a critical role in this process. See research article http://www.biomedcentral.com/1741-7007/8/105