A pilot study of same-day MRI-only simulation and treatment with MR-guided adaptive palliative radiotherapy (MAP-RT)

• Type of Material: Article
• Authors: Joshua P Schiff, Washington University in St. Louis; Borna Maraghechi, Washington University in St. Louis; Re-I Chin, Washington University in St. Louis; Alex Price, Washington University in St. Louis; Eric Laugeman, Washington University in St. Louis; Soumon Rudra, Emory University; Casey Hatscher, Washington University in St. Louis; Matthew B Spraker, Washington University in St. Louis; Shahed N Badiyan, Washington University in St. Louis; Lauren E Henke, Washington University in St. Louis; Olga Green, Varian Medical Systems; Hyun Kim, Washington University in St. Louis
• Language: English
• Date: 2023-03-01
• Publisher: Elsevier Inc
• Publication Version: Final Published Version
• Copyright Statement: © 2022 The Authors
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.ctro.2022.100561
• Title of Journal or Parent Work: Clinical and Translational Radiation Oncology
• Volume: 39
• Start Page: 100561
• End Page: 100561
• Grant/Funding Information: Funded by the Department of Radiation Oncology, Washington University School of Medicine in St. Louis.
• Keywords: Adaptive radiation; Treatment; MRI; Electron density calculations; CT Simulation-Free; Palliative radiation; Physics

Abstract

We conducted a prospective pilot study evaluating the feasibility of same day MRI-only simulation and treatment with MRI-guided adaptive palliative radiotherapy (MAP-RT) for urgent palliative indications (NCT#03824366). All (16/16) patients were able to complete 99% of their first on-table attempted fractions, and no grades 3–5 toxicities occurred.