Multi-patient study for coronary vulnerable plaque model comparisons: 2D/3D and fluid-structure interaction simulations

• Type of Material: Article
• Authors: Qingyu Wang, Southeast University; Dalin Tang, Southeast University; Liang Wang, Southeast University; Akiko Meahara, Columbia University; David Molony, Emory University; Habib Samady, Emory University; Jie Zheng, Washington University, St. Louis; Gary S Mintz, Columbia University; Gregg W Stone, Columbia University; Don Giddens, Emory University
• Language: English
• Date: 2021-03-23
• Publisher: SPRINGER HEIDELBERG
• Publication Version: Final Published Version
• Copyright Statement: © The Author(s) 2021
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1007/s10237-021-01450-8
• Title of Journal or Parent Work: BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
• Volume: 20
• Issue: 4
• Start Page: 1383
• End Page: 1397
• Grant/Funding Information: This research was supported in part by National Sciences Foundation of China grants 11972117, 11672001, and a Jiangsu Province Science and Technology Agency grant BE2016785.; Wang QY’s research was supported in part by Postgraduate Research & Practice Innovation Program of Jiangsu Province grant KYCX18_0156.
• Keywords: Technology; VH-IVUS; STRESS; RUPTURE; INTRAVASCULAR ULTRASOUND; Science & Technology; Life Sciences & Biomedicine; IVUS; PROGRESSION; Models comparison; ATHEROSCLEROTIC PLAQUES; Vulnerable plaque; Biophysics; Engineering; 3D FSI MODELS; Engineering, Biomedical; Patient-specific model; MECHANICS
• Research Categories: Engineering, Biomedical

Abstract

Several image-based computational models have been used to perform mechanical analysis for atherosclerotic plaque progression and vulnerability investigations. However, differences of computational predictions from those models have not been quantified at multi-patient level. In vivo intravascular ultrasound (IVUS) coronary plaque data were acquired from seven patients. Seven 2D/3D models with/without circumferential shrink, cyclic bending and fluid–structure interactions (FSI) were constructed for the seven patients to perform model comparisons and quantify impact of 2D simplification, circumferential shrink, FSI and cyclic bending plaque wall stress/strain (PWS/PWSn) and flow shear stress (FSS) calculations. PWS/PWSn and FSS averages from seven patients (388 slices for 2D and 3D thin-layer models) were used for comparison. Compared to 2D models with shrink process, 2D models without shrink process overestimated PWS by 17.26%. PWS change at location with greatest curvature change from 3D FSI models with/without cyclic bending varied from 15.07% to 49.52% for the seven patients (average = 30.13%). Mean Max-FSS, Min-FSS and Ave-FSS from the flow-only models under maximum pressure condition were 4.02%, 11.29% and 5.45% higher than those from full FSI models with cycle bending, respectively. Mean PWS and PWSn differences between FSI and structure-only models were only 4.38% and 1.78%. Model differences had noticeable patient variations. FSI and flow-only model differences were greater for minimum FSS predictions, notable since low FSS is known to be related to plaque progression. Structure-only models could provide PWS/PWSn calculations as good approximations to FSI models for simplicity and time savings in calculation.