Advances in understanding the interaction between the gut microbiota and adaptive mucosal immune responses

• Type of Material: Article
• Authors: Andrew S Neish, Emory University; Timothy Denning, Emory University
• Language: English
• Date: 2010-04-12
• Publisher: Faculty of 1000 Ltd
• Publication Version: Final Published Version
• Copyright Statement: © 2010 Faculty of 1000 Ltd
• License: Creative Commons Attribution-Noncommercial 3.0 Unported
• Final Published Version (URL): http://f1000.com/prime/reports/b/2/27
• Title of Journal or Parent Work: F1000 Biology Reports
• ISSN: 1757-594X
• Volume: 2
• Issue: 27
• Grant/Funding Information: The laboratory of ASN is supported by the National Institutes of Health (DK71604 and AI64462).
• Research Categories: Health Sciences, Pathology; Health Sciences, Immunology

Abstract

Commensal gut bacteria are necessary for the complete development of mucosal innate and adaptive immunity and thus may influence intestinal and systemic immune disorders. Recent work has advanced our understanding of this association by identification of a single taxon of the murine microbiota which can stimulate T-cell development and differentiation. It is hoped that further characterization of the mechanisms involved will enable targeted manipulation of the microbiota-immune system relationship.