The Effects of Prenatal Alcohol Exposure and Attention-Deficit/Hyperactivity Disorder on Psychopathology and Behavior

• Type of Material: Article
• Authors: Ashley L. Ware, San Diego State University; Jessica W. O'Brien, San Diego State University; Nicole Crocker, San Diego State University; Benjamin N. Deweese, San Diego State University; Scott C. Roesch, San Diego State University; Claire Coles, Emory University; Julie A Kable, Emory University; Phillip A. May, University of North Carolina; Wendy O. Kalberg, University of New Mexico; Elizabeth R. Sowell, University of Southern California; Kenneth Lyons Jones, University of California San Diego; Edward P. Riley, San Diego State University; Sarah N. Mattson, San Diego State University
• Language: English
• Date: 2013-03-01
• Publisher: Wiley: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2012 by the Research Society on Alcoholism.
• Final Published Version (URL): http://dx.doi.org/10.1111/j.1530-0277.2012.01953.x
• Title of Journal or Parent Work: Alcoholism: Clinical and Experimental Research
• ISSN: 0145-6008
• Volume: 37
• Issue: 3
• Start Page: 507
• End Page: 516
• Grant/Funding Information: Research described in this paper was supported by NIAAA grant numbers U01 AA014834 (Mattson), U24 AA014811 (Riley), U24 AA014818 (Barnett), and U24 AA014815 (Jones).; Additional support was provided by NIAAA grants U01/R01 AA011685 (May) and R01 AA015134 (May).; All or part of this work was done in conjunction with the Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD), which is funded by grants from the National Institute on Alcohol and Alcohol Abuse (NIAAA). Additional information about CIFASD can be found at www.cifasd.org.
• Keywords: FETAL ALCOHOL; PRESCHOOL-CHILDREN; Science & Technology; Fetal Alcohol Spectrum Disorders; Psychopathology; Fetal Alcohol Syndrome; DIAGNOSIS; LIFE; SPECTRUM DISORDERS; Substance Abuse; OUTCOMES; Hyperactivity Disorder; ADHD; DEFICIT HYPERACTIVITY DISORDER; SYMPTOMS; ADAPTIVE-BEHAVIOR; Life Sciences & Biomedicine; Psychiatric Disorders; Attention-Deficit
• Research Categories: Psychology, Behavioral; Health Sciences, Nutrition; Health Sciences, Obstetrics and Gynecology

Abstract

Background: This study examined prevalence of psychiatric disorders and behavioral problems in children with and without prenatal alcohol exposure (AE) and attention-deficit/hyperactivity disorder (ADHD). Methods: Primary caregivers of 344 children (8 to 16 years, M = 12.28) completed the Computerized Diagnostic Interview Schedule for Children-IV (C-DISC-4.0) and the Child Behavior Checklist (CBCL). Subjects comprised 4 groups: AE with ADHD (AE+, n = 85) and without ADHD (AE-, n = 52), and nonexposed with ADHD (ADHD, n = 74) and without ADHD (CON, n = 133). The frequency of specific psychiatric disorders, number of psychiatric disorders (comorbidity), and CBCL behavioral scores were examined using chi-square and analysis of covariance techniques. Results: Clinical groups had greater frequency of all psychiatric disorders, except for anxiety, where the AE- and CON groups did not differ. There was a combined effect of AE and ADHD on conduct disorder. For comorbidity, children with ADHD had increased psychiatric disorders regardless of AE, which did not have an independent effect on comorbidity. For CBCL scores, there were significant main effects of AE and ADHD on all scores and significant AE × ADHD interactions for Withdrawn/Depressed, Somatic Complaints, Attention, and all Summary scores. There was a combined effect of AE and ADHD on Externalizing, Total Problems, and Attention Problems. Conclusions: Findings indicate that ADHD diagnosis elevates children's risk of psychiatric diagnoses, regardless of AE, but suggest an exacerbated relation between AE and ADHD on conduct disorder and externalizing behavioral problems in children. Findings affirm a poorer behavioral prognosis for alcohol-exposed children with ADHD and suggest that more than 1 neurobehavioral profile may exist for individuals with AE.