The Effect of Maternal Postpartum Practices on Infant Gut Microbiota: A Chinese Cohort Study

• Type of Material: Article
• Authors: Ying Wang, Wuhan University; Yangun Liu, Wuhan University; Jinbing Bai, Emory University; Xiaoli Chen, Wuhan University
• Language: English
• Date: 2019-11-01
• Publisher: MDPI
• Publication Version: Final Published Version
• Copyright Statement: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.3390/microorganisms7110511
• Title of Journal or Parent Work: Microorganisms
• Volume: 7
• Issue: 11
• Grant/Funding Information: This research was funded by Natural Science Foundation of Hubei Province, grant number 2017CFB343, and The Key Independent Scientific Research Project of WuHan University School of Health Sciences, grant number JSZD2016001.
• Keywords: ASSOCIATION; culture; Chinese women; ANTIBIOTIC USE; SHAPES; infant; DISEASE; BACTERIAL-COLONIZATION; PRENATAL STRESS; TRANSMISSION; microbiota; Science & Technology; Life Sciences & Biomedicine; THERAPY; Microbiology; probiotics consumption; BODY SITES; COMMENSAL BACTERIA; postpartum practices

Abstract

(1) Background: The human gut microbiota at early life is shaped by numerous factors, especially factors from mothers, which have huge influence on infants’ gut microbiotas. The aim of this study was to investigate the effect of maternal adherence to Chinese traditional postpartum practices of “doing the month” on the development of infant gut microbiota at 6-month postpartum. (2) Methods: A cohort of 62 Chinese women at late pregnancy was recruited from a tertiary general hospital in a central region of China. The participants and their babies were followed up to 6 months postpartum. Finally, 50 mother-infant dyads were enrolled in the study. Women’s adherence to the traditional postpartum practices was measured by adherence to doing the month practices (ADP). Infant fecal samples were collected at six months of age and were analyzed using 16S rRNA V3 and V4 gene region sequences. (3) Results: Ruminococcus gnavus was significantly less abundant in infants whose mothers had a better adherence to the traditional postpartum practices of “doing the month.” Infants receiving Clostridium-butyricum during the first month after delivery had a significant dominance of Escherichia/Shigella. (4) Conclusions: Adherence to the traditional postpartum practices of “doing the month” can impact an infant’s gut microbiota at 6 months of age. Infants receiving probiotics during the first month after delivery had a significant dominance of opportunistic pathogens.