Influenza or Meningococcal Immunization During Pregnancy and Mortality in Women and Infants A Pooled Analysis of Randomized Controlled Trials

• Type of Material: Article
• Authors: Dayna R. Clark, Emory University; Saad Omer, Emory University; Milagritos D. Tapia, University of Maryland; Marta C. Nunes, University of Witwatersrand; Clare L. Cutland, University of Witwatersrand; James M. Tielsch, George Washington University; Niteen Wairagkar, Bill & Melinda Gates Foundation; Shabir A. Madhi, University of Witwatersrand
• Language: English
• Date: 2020-07-01
• Publisher: Lippincott Williams & Wilkins
• Publication Version: Final Published Version
• Copyright Statement: © 2020 The Author(s). Published by Wolters Kluwer Health, Inc.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1097/INF.0000000000002629
• Title of Journal or Parent Work: Pediatric Infectious Disease Journal
• Volume: 39
• Issue: 7
• Start Page: 641
• End Page: 644
• Grant/Funding Information: The 3 trials in Mali, South Africa and Nepal as well as this pooled analysis were funded by the Bill & Melinda Gates Foundation.; This pooled analysis received research funding from the Bill & Melinda Gates Foundation.
• Keywords: Science & Technology; Infectious Diseases; Life Sciences & Biomedicine; Vaccine; randomized controlled trial; Immunology; Phase 4; influenza; Mali; meningococcal; maternal immunization; Nepal; Pediatrics; vaccine; Mothers
• Research Categories: Health Sciences, Public Health; Health Sciences, Obstetrics and Gynecology; Health Sciences, Immunology; Health Sciences, Epidemiology

Abstract

This analysis includes pooled data from 2 placebo-controlled maternal influenza immunization trials, with a separate analysis on a meningococcal conjugate vaccine-controlled maternal influenza immunization trial. Maternal influenza immunization was not associated with infant or maternal all-cause mortality in placebo-controlled trials. In the meningococcal conjugate vaccine-controlled trial, there were fewer deaths during low or any influenza circulation weeks among infants whose mothers received meningococcal conjugate vaccine. ClinicalTrials.gov identifiers: NCT01430689, NCT01034254 and NCT02465190.