Cardiovascular Biomarkers in Chronic Kidney Disease: State of Current Research and Clinical Applicability

• Type of Material: Article
• Authors: Luis D'Marco, Unidad Avanzada de Investigación y Diagnostico Ecográfico y Renal; Antonio Bellasi, University of Milan; Paolo Raggi, Emory University
• Language: English
• Date: 2015-01-01
• Publisher: Hindawi Publishing Corporation
• Publication Version: Final Published Version
• Copyright Statement: © 2015 Luis D'Marco et al.
• License: Creative Commons Attribution 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1155/2015/586569
• Title of Journal or Parent Work: Disease Markers
• ISSN: 0278-0240
• Volume: 2015
• Start Page: 586569
• End Page: 586569
• Keywords: Science & Technology; CORONARY-ARTERY-DISEASE; Research & Experimental Medicine; STAGE RENAL-DISEASE; DECOMPENSATED HEART-FAILURE; C-REACTIVE PROTEIN; CARDIAC TROPONIN-T; Pathology; Biotechnology & Applied Microbiology; PREDICTS ALL-CAUSE; FIBROBLAST GROWTH FACTOR-23; BRAIN NATRIURETIC PEPTIDE; Genetics & Heredity; GELATINASE-ASSOCIATED LIPOCALIN; Life Sciences & Biomedicine; PERITONEAL-DIALYSIS PATIENTS; Medicine, Research & Experimental
• Research Categories: Health Sciences, General

Abstract

The high incidence of cardiovascular events in chronic kidney disease (CKD) warrants an accurate evaluation of risk aimed at reducing the burden of disease and its consequences. The use of biomarkers to identify patients at high risk has been in use in the general population for several decades and has received mixed reactions in the medical community. Some practitioners have become staunch supporters and users while others doubt the utility of biomarkers and rarely measure them. In CKD patients numerous markers similar to those used in the general population and others more specific to the uremic population have emerged; however their utility for routine clinical application remains to be fully elucidated. The reproducibility and standardization of the serum assays are serious limitations to the broad implementation of these tests. The lack of focused research and validation in randomized trials rather than ad hoc measurement of multiple serum markers in observational studies is also cause for concern related to the clinical applicability of these markers. We review the current literature on biomarkers that may have a relevant role in field of nephrology.