Insulators as mediators of intra- and inter-chromosomal interactions: a common evolutionary theme

• Type of Material: Article
• Authors: Chin-Tong Ong, Emory University; Victor Corces, Emory University
• Language: English
• Date: 2009
• Publisher: BioMed Central
• Publication Version: Final Published Version
• Copyright Statement: © 2009 BioMed Central Ltd
• License: Creative Commons Attribution 2.0 Generic
• Final Published Version (URL): http://jbiol.com/content/8/8/73
• Title of Journal or Parent Work: Journal of Biology
• ISSN: 1478-5854
• Volume: 8
• Issue: 8
• Start Page: 73
• End Page: 73
• Grant/Funding Information: Work in the authors' laboratory is supported by Public Health Service Award GM35463 from the National Institutes of Health.
• Research Categories: Biology, Genetics; Biology, Molecular

Abstract

Insulator elements mediate intra- and inter-chromosomal interactions. The insulator protein CCCTC-binding factor (CTCF) is important for insulator function in several animals but a report in BMC Molecular Biology shows that Caenorhabditis elegans, yeast and plants lack CTCF. Alternative proteins may have a similar function in these organisms.