Lesion of the centromedian thalamic nucleus in MPTP-treated monkeys

• Type of Material: Article
• Authors: Jose L. Lanciego, University of Navarra; Maria C. Rodriguez-Oroz, University of Navarra; Francisco J. Blesa, University of Navarra; Lydia Alvarez-Erviti, University of Navarra; Jorge Guridi, University of Navarra; Pedro Barroso-Chinea, University of Navarra; Yoland Smith, Emory University; Jose A. Obeso, University of Navarra
• Language: English
• Date: 2008-04-15
• Publisher: Wiley
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2008 Movement Disorder Society.
• Final Published Version (URL): http://dx.doi.org/10.1002/mds.21906
• Title of Journal or Parent Work: Movement Disorders
• ISSN: 0885-3185
• Volume: 23
• Issue: 5
• Start Page: 708
• End Page: 715
• Grant/Funding Information: Supported by grants from the Michael J. Fox Foundation; Ministerio de Educación y Ciencia refs: BFU2006-06744 and SAF2005-08416-C02-01; FIS refs: PI051037 and 013/2003; Fundación de Investigación Médica Mutua Madrilenña; and by the agreement between FIMA and the “UTE project FIMA.”
• Keywords: MPTP monkey model; Clinical Neurology; EFFERENT CONNECTIONS; MEDIAN-PARAFASCICULAR COMPLEX; Science & Technology; DEEP BRAIN-STIMULATION; Neurosciences & Neurology; GLOBUS-PALLIDUS; PARKINSONS-DISEASE; SUBTHALAMIC NUCLEUS; SQUIRREL-MONKEY; Parkinson's disease; kainic acid lesion; POSSIBLE INVOLVEMENT; TOURETTES-SYNDROME; Life Sciences & Biomedicine; intralaminar thalamic nuclei; BASAL GANGLIA
• Research Categories: Biology, Neuroscience

Abstract

The caudal intralaminar nuclei are a major source of glutamatergic afferents to the basal ganglia. Experiments in the 6-hydroxydopamine rat model have shown that the parafascicular nucleus is overactive and its lesion alleviates basal ganglia neurochemical abnormalities associated with dopamine depletion. Accordingly, removal of this excitatory innervation of the basal ganglia could have a beneficial value in the parkinsonian state. To test this hypothesis, unilateral kainate-induced chemical ablation of the centromedian thalamic nucleus (CM) has been performed in MPTP-treated monkeys. Successful lesions restricted to the CM boundaries (n = 2) without spreading over other neighboring thalamic nuclei showed an initial, short-lasting, and mild change in the parkinsonian motor scale but no effect against levodopa-induced dyskinesias. The lack of significant and persistent motor improvement leads us to conclude that unilateral selective lesion of the CM alone cannot be considered as a suitable surgical approach for the treatment of PD or levodopa-induced dyskinesias. The role of the caudal intralaminar nuclei in the pathophysiology of movement disorders of basal ganglia origin remains to be clarified.