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Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson’s Disease

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Last modified
  • 05/21/2025
Type of Material
Authors
    Weiqi Zeng, Huazhong University of Science and TechnologyWenliang Fan, Huazhong University of Science and TechnologyXiangchuang Kong, Huazhong University of Science and TechnologyXiaoming Liu, Huazhong University of Science and TechnologyLing Liu, Huazhong University of Science and TechnologyZiqin Cao, Emory UniversityXiaoqian Zhang, Huazhong University of Science and TechnologyXiaoman Yang, Huazhong University of Science and TechnologyChi Cheng, Huazhong University of Science and TechnologyYi Wu, Huazhong University of Science and TechnologyYu Xu, Huazhong University of Science and TechnologyXuebing Cao, Huazhong University of Science and TechnologyYan Xu, Huazhong University of Science and Technology
Language
  • English
Date
  • 2022-02-14
Publisher
  • Frontiers Media S.A.
Publication Version
Copyright Statement
  • © 2022 Zeng, Fan, Kong, Liu, Liu, Cao, Zhang, Yang, Cheng, Wu, Xu, Cao and Xu.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 14
Start Page
  • 783634
End Page
  • 783634
Grant/Funding Information
  • This study was supported by grant from the National key Research and Development Program of China (2017YFC1310300), National Natural Science Foundation of China (81974200, 81873734, 81701673, and 81671108), and the Hubei Provincial Natural Science Foundation of China (Grant No. 2019CFB497).
Supplemental Material (URL)
Abstract
  • The aim of our study was to investigate differences in whole brain connectivity at different levels between drug-naïve individuals with early Parkinson’s disease (PD) and healthy controls (HCs). Resting-state functional magnetic resonance imaging data were collected from 47 patients with early-stage, drug-naïve PD and 50 HCs. Functional brain connectivity was analyzed at the integrity, network, and edge levels; UPDRS-III, MMSE, MOCA, HAMA, and HAMD scores, reflecting the symptoms of PD, were collected for further regression analysis. Compared with age-matched HCs, reduced functional connectivity were mainly observed in the visual (VSN), somatomotor (SMN), limbic (LBN), and deep gray matter networks (DGN) at integrity level [p < 0.05, false discovery rate (FDR) corrected]. Intra-network analysis indicated decreased functional connectivity in DGN, SMN, LBN, and ventral attention networks (VAN). Inter-network analysis indicated reduced functional connectivity in nine pairs of resting-state networks. At the edge level, the LBN was the center of abnormal functional connectivity (p < 0.05, FDR corrected). MOCA score was associated with the intra-network functional connectivity strength (FC) of the DGN, and inter-network FC of the DGN-VAN. HAMA and HAMD scores were associated with the FC of the SMN and DGN, and either the LBN or VAN, respectively. We demonstrated variations in whole brain connections of drug-naïve patients with early PD. Major changes involved the SMN, DGN, LBN, and VSN, which may be relevant to symptoms of early PD. Additionally, our results support PD as a disconnection syndrome.
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Keywords
Research Categories
  • Health Sciences, Radiology
  • Chemistry, General

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