Idiopathic Intracranial Hypertension: Relation Between Obesity and Visual Outcomes

• Type of Material: Article
• Authors: Aimee J. Szewka, Emory University; Beau Benjamin Bruce, Emory University; Nancy J. Newman, Emory University; Valerie Biousse, Emory University
• Language: English
• Date: 2013-03
• Publisher: Lippincott, Williams & Wilkins
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2013 by North American Neuro-Ophthalmology Society
• Final Published Version (URL): http://journals.lww.com/jneuro-ophthalmology/pages/articleviewer.aspx?year=2013&issue=03000&article=00002&type=abstract
• Title of Journal or Parent Work: Journal of Neuro-Ophthalmology
• ISSN: 1070-8022
• Volume: 33
• Issue: 1
• Start Page: 4
• End Page: 8
• Grant/Funding Information: This study was supported in part by a departmental grant (Department of Ophthalmology) from Research to Prevent Blindness, Inc., New York, by core grant P30-EY06360 (Department of Ophthalmology). Dr. Bruce receives research support from the NIH/NEI (K23-EY019341) and received the American Academy of Neurology Practice Research Fellowship. Dr. Newman is a recipient of the Research to Prevent Blindness Lew R. Wasserman Merit Award.
• Keywords: Visual Outcomes; Severe Vision Loss; Idiopathic Intracranial Hypertension; Body Mass Index; Obesity; Risk Factors
• Research Categories: Biology, Neuroscience; Health Sciences, Opthamology

Abstract

Background Increased body mass index (BMI) has been associated with increased risk of idiopathic intracranial hypertension (IIH), but the relationship of BMI to visual outcomes in IIH is unclear. Methods A retrospective chart review of all adult cases of IIH satisfying the modified Dandy criteria seen at our institution between 1989 and 2010 was performed. Demographics, diagnostic evaluations, baseline visit and last follow-up examination data, treatment and visual outcome data were collected in a standardized fashion. Groups were compared and logistic regression was used to evaluate the relationship of BMI to severe visual loss, evaluating for interaction and controlling for potential confounders. Results Among 414 consecutive IIH patients, 158 had BMI≥40 (WHO Obese Class III), and 172 had BMI 30–39.9. Patients with BMI≥40 were more likely to have severe papilledema at first neuro-ophthalmology encounter than those with a lower BMI (p=0.02). There was a trend toward more severe visual loss in one or both eyes at last follow up among those patients with BMI≥40 (18 vs. 11%, p=0.067). Logistic regression modelling found that ten unit (kg/m2) increases in BMI increased the odds of severe visual loss by 1.4 times (95%CI: 1.03–1.91, p=0.03), after controlling for sex, race, diagnosed hypertension, and diagnosed sleep apnea. Conclusion Our finding of a trend for severe papilledema and visual loss associated with increasing BMI suggests that very obese IIH patients should be closely monitored for progression of visual field loss.