Chronic recurrent multifocal osteomyelitis causing optic neuropathy

• Type of Material: Article
• Authors: Joel Mudri, Royal Perth Hospital; Jane Lock, Royal Perth Hospital; Omkar Phadke, Emory University; Kelly Rouster-Stevens, Emory University; Joon H Kim, Emory University; Jason Peragallo, Emory University
• Language: English
• Date: 2022-02-01
• Publisher: MOSBY-ELSEVIER
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2021 American Association for Pediatric Ophthalmology and Strabismus. Published by Elsevier Inc. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.jaapos.2021.09.003
• Title of Journal or Parent Work: JOURNAL OF AAPOS
• Volume: 26
• Issue: 1
• Start Page: 43
• End Page: 46
• Grant/Funding Information: Supported in part by an ophthalmology departmental core grant from the NIH/NEI (P30 EY006360).
• Keywords: Pediatrics; INVOLVEMENT; Ophthalmology; SAPHO; Life Sciences & Biomedicine; Science & Technology

Abstract

We present the case of an 8-year-old girl with chronic recurrent multifocal osteomyelitis (CRMO) involving the orbit and facial bone and causing left optic neuropathy. She presented with intermittent left periorbital swelling and a history of CRMO diagnosed 5 years earlier. Her disease responded well to adalimumab; however, delayed presentation resulted in permanent unilateral optic nerve atrophy and reduced vision. Orbital inflammatory disease is a rare manifestation of CRMO, and early recognition of the disease and treatment may prevent irreversible vision loss.[Formula presented]