Publication

Editorial: Non-Coding RNAs and Human Diseases

Downloadable Content

Persistent URL
Last modified
  • 05/20/2025
Type of Material
Authors
    Yujing Li, Emory UniversityGe Shan, University of Science and Technology of ChinaZhao-Qian Teng, Institute of ZoologyThomas Wingo, Emory University
Language
  • English
Date
  • 2020-05-25
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2020 Li, Shan, Teng and Wingo.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 11
Grant/Funding Information
  • This work was supported by NIH grants RF1 AG057470, U01 AG061357, P50 AG025688, R56 AG062256, R56 AG060757, and R01 AG056533 (to TW).
Abstract
  • Non-coding RNA (ncRNA) are functional RNA molecules that are not translatable into proteins (Djebali et al., 2012; Lonsdale et al., 2013; Forrest et al., 2014). Initially, ncRNAs referred to tRNAs and rRNAs (Brown et al., 1992; St Laurent et al., 2015). Recent technical advances have led to the discovery and characterization of many new classes of ncRNAs (Hüttenhofer and Vogel, 2006). These new ncRNAs species include snRNAs, snoRNAs, miRNAs, siRNAs, piRNAs, exRNAs, long non-coding RNA (lncRNAs), scaRNAs, and circRNAs (He and Hannon, 2004; Gu et al., 2007; Esteller, 2011; Redzic et al., 2014; Wu and Yang, 2015). While not all of their functions are known, many of the ncRNA species appear to play essential roles regulating transcription and translation of genes and transcription of ncRNAs themselves. Thus, there is little surprise that ncRNAs are identified as playing important roles in normal physiologic processes, complex human traits, and human diseases (Diederichs et al., 2016; Li et al., 2018; Fernandes et al., 2019; Vijayan and Reddy, 2020). This special issue focused on the ncRNA, particularly circRNAs, lncRNAs, miRNAs, and their role in human disease. The aim of this issue is to provide a broad overview of current research on the diverse work being done to elucidate the role of ncRNAs in disease. A major theme that emerged was the potential role of miRNAs as prognostic markers or biomarkers of disease.
Author Notes
Keywords
Research Categories
  • Health Sciences, Immunology
  • Biology, Genetics
  • Biology, Cell
  • Biology, Anatomy

Tools

Relations

In Collection:

Items

Thumbnail Title File Description Date Uploaded Visibility Actions
file details Publication File - vnrqb.pdf Primary Content 2025-04-28 Public Download