Challenges in assessing the efficacy of systemic corticosteroids for severe wheezing episodes in preschool children

• Type of Material: Article
• Authors: Theresa W. Guilbert, University of Cincinnati; Leonard B. Bacharier, Washington University in St. Louis; David T. Mauger, Pennsylvania State University; Wanda Phipatanakul, Boston Children's Hospital; Stanley J. Szefler, Children's Hospital of Colorado; Susan Boehmer, Pennsylvania State University; Avraham Beigelman, Washington University in St. Louis; Anne Fitzpatrick, Emory University; Karen DeMuth, Emory University; Timothy Beaty, Emory University
• Language: English
• Date: 2019-05-01
• Publisher: MOSBY-ELSEVIER
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2019 American Academy of Allergy, Asthma & Immunology
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.jaci.2018.10.071
• Title of Journal or Parent Work: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
• Volume: 143
• Issue: 5
• Start Page: 1934
• End Page: +
• Grant/Funding Information: Funded by the National Heart, Lung and Blood Institute.
• Keywords: ASTHMA EXACERBATIONS; Lower respiratory tract infections; oral corticosteroids; TODDLERS; ORAL CORTICOSTEROIDS; THERAPY; Life Sciences & Biomedicine; efficacy; Science & Technology; multi-center clinical trial; Preschool-aged Children; Immunology; Allergy; Preschool Wheezing
• Research Categories: Health Sciences, Medicine and Surgery; Health Sciences, Immunology

Abstract

This letter addresses the controversial issue of the use of oral corticosteroids during wheezing exacerbations in preschool-aged children by demonstrating findings of a prematurely terminated multi-center clinical trial, discussing lessons learned, and suggesting future directions.