Skin Barrier Function: The Interplay of Physical, Chemical, and Immunologic Properties

• Type of Material: Article
• Authors: Paola Baker, Emory University; Christina Huang, Emory University; Rakan Hisham Radi, Emory University; Samara B. Moll, Emory University; Emmanuela Jules, Emory University; Jack L. Arbiser, Metroderm/United Derm Partners
• Language: English
• Date: 2023-11-30
• Publisher: MDPI
• Publication Version: Final Published Version
• Copyright Statement: © 2023 by the authors.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): https://doi.org/10.3390/cells12232745
• Title of Journal or Parent Work: Cells
• Volume: 12
• Issue: 23
• Start Page: 2745
• Grant/Funding Information: This research received no external funding.
• Keywords: acid mantle; psoriasis; atopic dermatitis; dermatology; skin barrier
• Research Categories: Health Sciences, General; Biology, Physiology

Abstract

An intact barrier function of the skin is important in maintaining skin health. The regulation of the skin barrier depends on a multitude of molecular and immunological signaling pathways. By examining the regulation of a healthy skin barrier, including maintenance of the acid mantle and appropriate levels of ceramides, dermatologists can better formulate solutions to address issues that are related to a disrupted skin barrier. Conversely, by understanding specific skin barrier disruptions that are associated with specific conditions, such as atopic dermatitis or psoriasis, the development of new compounds could target signaling pathways to provide more effective relief for patients. We aim to review key factors mediating skin barrier regulation and inflammation, including skin acidity, interleukins, nuclear factor kappa B, and sirtuin 3. Furthermore, we will discuss current and emerging treatment options for skin barrier conditions.