Publication

The NFκB signaling system in the generation of B-cell subsets: from germinal center B cells to memory B cells and plasma cells

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Last modified
  • 06/25/2025
Type of Material
Authors
    Koushik Roy, University of UtahMainak Chakraborty, Indian Council of Medical Research-National Institute of Cholera and Enteric DiseasesAshok Kumar, University of UtahAsit Kumar Manna, University of UtahNeeladri Sekhar Roy, Emory University
Language
  • English
Date
  • 2023-12-10
Publisher
  • Frontiers Media S.A
Publication Version
Copyright Statement
  • Copyright © 2023 Roy, Chakraborty, Kumar, Manna and Roy.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 14
Start Page
  • 1185597
Grant/Funding Information
  • This study is funded by the Department of Pathology, University of Utah and the American Society of Hematology Scholar Award to KR.
Abstract
  • Memory B cells and antibody-secreting cells are the two prime effector B cell populations that drive infection- and vaccine-induced long-term antibody-mediated immunity. The antibody-mediated immunity mostly relies on the formation of specialized structures within secondary lymphoid organs, called germinal centers (GCs), that facilitate the interactions between B cells, T cells, and antigen-presenting cells. Antigen-activated B cells may proliferate and differentiate into GC-independent plasmablasts and memory B cells or differentiate into GC B cells. The GC B cells undergo proliferation coupled to somatic hypermutation of their immunoglobulin genes for antibody affinity maturation. Subsequently, affinity mature GC B cells differentiate into GC-dependent plasma cells and memory B cells. Here, we review how the NFκB signaling system controls B cell proliferation and the generation of GC B cells, plasmablasts/plasma cells, and memory B cells. We also identify and discuss some important unanswered questions in this connection.
Author Notes
Keywords
Research Categories
  • Health Sciences, Immunology
  • Biology, Molecular
  • Biology, Cell

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