Impact of Hypothyroidism on Outcomes of Percutaneous Coronary Intervention with Coronary Atherectomy for Calcified Coronary Lesions: A Propensity-matched Analysis.

• Type of Material: Article
• Authors: Rupak Desai, Atlanta Veterans Affairs Medical Center; Hemant Goyal, Mercer University; Gautam Kumar, Emory University; Rajesh Sachdeva, Emory University
• Language: English
• Date: 2018-05-09
• Publisher: Cureus, Inc.
• Publication Version: Final Published Version
• Copyright Statement: © 2018, Desai et al.
• License: Creative Commons Attribution 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.7759/cureus.2600
• Title of Journal or Parent Work: Cureus
• ISSN: 2168-8184
• Volume: 10
• Issue: 5
• Start Page: e2600
• End Page: e2600
• Keywords: outcomes; percutaneous coronary intervention; hospitalization cost; coronary atherosclerosis; all-cause mortality; pci; calcified lesions; cardiovascular complications; coronary atherectomy; hypothyroidism
• Research Categories: Health Sciences, General; Health Sciences, Medicine and Surgery

Abstract

Overt and subclinical hypothyroid states have been depicted as risk factors for a more prominent level of coronary calcification. The utilization of coronary atherectomy with percutaneous coronary intervention (PCI) is on the ascent over the past few years as lesions that are more complex are now attempted with a percutaneous approach. However, the real-world data on hypothyroid status influencing PCI with coronary atherectomy outcomes is very limited. Therefore, we proposed to investigate the outcomes of percutaneous coronary intervention with coronary atherectomy in hypothyroid patients using the largest inpatient database in the United States (US), the National Inpatient Sample (NIS). To minimize the selection bias, we surveyed and compared the outcomes in both the unmatched and propensity-score matched euthyroid and hypothyroid cohorts. Concisely, this propensity-matched analysis, using the largest population-based sample in the US, has established higher cardiovascular comorbidities and worse clinical outcomes of PCI with coronary atherectomy owing to clinical hypothyroidism.