Oxidative Balance Score during Pregnancy Is Associated with Oxidative Stress in the CANDLE Study

• Type of Material: Article
• Authors: Frances A Tylavsky, University of Tennessee, Memphis; L Han, University of Tennessee, Memphis; Lauren MS Taylor, University of Tennessee, Memphis; Alex W Mason, University of Tennessee, Memphis; Kecia N Carroll, Icahn School of Medicine at Mount Sinai; Nicole R Bush, University of California San Francisco; Kaja Z LeWinn, University of California San Francisco; Melissa M Melough, Seattle Children’s Research Institute; Terryl Hartman, Emory University; Qi Zhao, University of Tennessee, Memphis
• Language: English
• Date: 2022-06-01
• Publisher: MDPI
• Publication Version: Final Published Version
• Copyright Statement: © 2022 by the authors.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.3390/nu14112327
• Title of Journal or Parent Work: NUTRIENTS
• Volume: 14
• Issue: 11
• Grant/Funding Information: The CANDLE study was supported by the Urban Child Institute, the University of Tennessee Health Science Center, and the National Institutes of Health grants (1R01HL109977, 1UG3OD023271-01, 4UH3OD023271-03 and 5R01HL109977-05).
• Keywords: dietary intake; BIOMARKERS; Nutrition & Dietetics; HEALTHY EATING INDEX; anti-oxidant balance; pregnancy; lifestyle; oxidative stress; VITAMIN-D; QUANTIFICATION; SERUM; RISK; Science & Technology; isoprostanes; PREVENTION; ISOPROSTANES; Life Sciences & Biomedicine
• Research Categories: Health Sciences, Medicine and Surgery; Health Sciences, Mental Health; Health Sciences, Epidemiology

Abstract

The objective of this study was to calculate an oxidative balance score (OBS) utilizing diet and lifestyle information collected from 1322 women during the second trimester of pregnancy in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood study. An energy-adjusted OBS was calculated using nutrient information from a Food Frequency Questionnaire (FFQ), lifestyle measures, and plasma folate and vitamin D levels. Using the least absolute shrinkage and selection operator method, 91 food items from the FFQ were selected and they accounted for 82% of the variance in the OBS, with cruciferous vegetables, citrus fruits, fruit juice, and coffee being among the highest anti-oxidant predictors, and red meats and alcohol among the highest pro-oxidant contributors. Urinary F2-isoprostane, an objective indicator of oxidative stress, was lower with increasing OBS quintiles in a stairstep manner (p for trend = 0.0003), suggesting the possible utility of the OBS as an indicator of oxidative stress. The OBS was moderately correlated with the Healthy Eating Index (correlation coefficient = 0.6076), suggesting it provides a distinct measure of a healthy diet. In conclusion, the OBS may serve as a valid reflective indicator of urinary F2-isoprostanes and an epidemiological tool to inform intervention studies, in order to minimize oxidative stress during pregnancy.