A role for B cells in facilitating defense against an NK cell-sensitive lung metastatic tumor is revealed by stress

• Type of Material: Article
• Authors: Harlan P. Jones, University of North Texas; Beau Aldridge, Emory University; Katherine A Williams, Emory University; Jay Weiss, Emory University
• Language: English
• Date: 2017-12-15
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2017 Elsevier B.V.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.jneuroim.2017.10.017
• Title of Journal or Parent Work: Journal of Neuroimmunology
• ISSN: 0165-5728
• Volume: 313
• Start Page: 99
• End Page: 108
• Grant/Funding Information: This work was supported by the National Institutes of Health Grant 5 R01CA87923-03.
• Keywords: OVARIAN-CANCER; DENDRITIC CELLS; Life Sciences & Biomedicine; NATURAL-KILLER-CELLS; BREAST-CANCER; Stress; Neurosciences & Neurology; Lung; Metastasis; PSYCHOLOGICAL STRESS; SOCIAL STRESS; IMMUNE FUNCTION; Immunology; Neurosciences; REGULATORY T-CELLS; Science & Technology; COPING STRATEGIES; PSYCHOSOCIAL FACTORS; Immunity
• Research Categories: Health Sciences, Immunology; Biology, Neuroscience

Abstract

Stressors impair immune defenses and pose risks among cancer patients. Natural Killer cells are not the sole immune defense against tumor development. Utilizing an NK-sensitive tumor model, this study evaluated immune effects to stress and determined whether lung metastasis resulted from B cells' inability to augment tumorlytic function. Lung metastasis directly correlated with delayed lung B cell accumulation compared to NK, and T cells. Decreased interleukin-12 cytokine and CD80+ molecule expression by B cells correlated with decreased tumor lysis and increased tumor development. Thus, tumor defenses in the lung given stress exposure can depend on the B cell function.