Regulation of antimicrobial resistance by extracytoplasmic function (ECF) sigma factors

• Type of Material: Article
• Authors: Emily C. Woods, Emory University; Shonna McBride, Emory University
• Language: English
• Date: 2017-04-01
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2017 Institut Pasteur
• Final Published Version (URL): http://dx.doi.org/10.1016/j.micinf.2017.01.007
• Title of Journal or Parent Work: Microbes and Infection
• ISSN: 1286-4579
• Volume: 19
• Issue: 4-5
• Start Page: 238
• End Page: 248
• Grant/Funding Information: This research was supported by the U.S. National Institutes of Health through research grants DK087763, DK101870, AI109526 and AI116933 to S.M.M. and T32 GM008169 to E.C.W.
• Keywords: INTRINSIC ANTIBIOTIC-RESISTANCE; CONFERS LYSOZYME RESISTANCE; STREPTOMYCES-COELICOLOR A3(2); MUCOID PSEUDOMONAS-AERUGINOSA; ENTERICA SEROVAR TYPHIMURIUM; Extracytoplasmic function sigma factors; Life Sciences & Biomedicine; BACILLUS-SUBTILIS; Regulation; GLOBAL GENE-EXPRESSION; ECF sigma factors; BETA-LACTAM RESISTANCE; Science & Technology; Immunology; Antimicrobial resistance; Infectious Diseases; Microbiology; ENVELOPE STRESS RESPONSES; ESCHERICHIA-COLI SIGMA(E)
• Research Categories: Biology, Microbiology; Health Sciences, Immunology; Health Sciences, Medicine and Surgery

Abstract

Extracytoplasmic function (ECF) sigma factors are a subfamily of σ 70 sigma factors that activate genes involved in stress-response functions. In many bacteria, ECF sigma factors regulate resistance to antimicrobial compounds. This review will summarize the ECF sigma factors that regulate antimicrobial resistance in model organisms and clinically relevant pathogens.