Invasive meningococcal disease due to nongroupable Neisseria meningitidis—active bacterial core surveillance sites, 2011–2016

• Type of Material: Article
• Authors: Lucy A McNamara, National Center for Immunization and Respiratory Diseases; Caelin C Potts, National Center for Immunization and Respiratory Diseases; Amy Blain, National Center for Immunization and Respiratory Diseases; Nadav Topaz, National Center for Immunization and Respiratory Diseases; Mirasol Apostol, California Emerging Infections Program; Nisha B Alden, Colorado Disease Control and Environmental Epidemiology; Susan Petit, Connecticut Department of Public Health; Monica Farley, Emory University; Lee H Harrison, University of Pittsburgh; Lori Triden, Minnesota Department of Health; Alison Muse, New York State Department of Health; Tasha Poissant, Oregon Health Authority; Xin Wang, National Center for Immunization and Respiratory Diseases; Jessica R MacNeil, National Center for Immunization and Respiratory Diseases
• Language: English
• Date: 2019-01-01
• Publisher: Oxford University Press (OUP)
• Publication Version: Final Published Version
• Copyright Statement: © 2019 Oxford University Press. All rights reserved.
• License: Creative Commons Creative Commons CC0 1.0 Universal
• Final Published Version (URL): http://dx.doi.org/10.1093/ofid/ofz190
• Title of Journal or Parent Work: Open Forum Infectious Diseases
• ISSN: 2328-8957
• Volume: 6
• Issue: 5
• Start Page: ofz190
• End Page: ofz190
• Grant/Funding Information: This work was supported by the United States Centers for Disease Control and Prevention Emerging Infections Program cooperative agreement (CK17-1701), which funded Active Bacterial Core surveillance system sites.
• Keywords: meningococcal disease; complement component deficiency; Neisseria meningitidis; nongroupable
• Research Categories: Health Sciences, Pathology; Health Sciences, Epidemiology

Abstract

We characterized 22 meningococcal disease cases due to nongroupable Neisseria meningitidis, a rare cause of invasive disease. Disease presentation and severity were similar to those for serogroupable meningococcal disease. However, 7 (32%) patients had complement deficiency or abnormal complement testing results, highlighting the importance of complement testing for nongroupable cases.