Molecular and Biochemical Aspects of the Retina on Refraction

• Type of Material: Article
• Authors: Rana Chakraborty, Emory University; Machelle Pardue, Emory University
• Language: English
• Date: 2015-01-01
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2015 Elsevier Inc.
• Final Published Version (URL): http://dx.doi.org/10.1016/bs.pmbts.2015.06.013
• Title of Journal or Parent Work: Progress in Molecular Biology and Translational Science
• ISSN: 1877-1173
• Volume: 134
• Start Page: 249
• End Page: 267
• Keywords: HOMEOBOX GENE VSX1; STATIONARY NIGHT BLINDNESS; LENS-INDUCED MYOPIA; Biochemistry & Molecular Biology; NITRIC-OXIDE SYNTHASE; INHIBITOR L-NAME; Life Sciences & Biomedicine; PIRENZEPINE OPHTHALMIC GEL; FORM-DEPRIVATION MYOPIA; OCULAR GROWTH; Ophthalmology; Science & Technology; BIPOLAR CELL-DIFFERENTIATION; EYE GROWTH
• Research Categories: Health Sciences, Opthamology; Health Sciences, Rehabilitation and Therapy

Abstract

Mutant mouse models with specific visual pathway defects offer an advantage to comprehensively investigate the role of specific pathways/neurons involved in refractive development. In this review, we will focus on recent studies using mouse models that have provided insight into retinal pathways and neurotransmitters controlling refractive development. Specifically, we will examine the contributions of rod and cone photoreceptors and the ON and OFF retinal pathways to visually driven eye growth with emphasis on dopaminergic mechanisms.