Division of labor, plasticity, and crosstalk between dendritic cell subsets

• Type of Material: Article
• Authors: Bali Pulendran, Emory University; Hua Tang, Emory Vaccine Center; Timothy Denning, Emory University
• Language: English
• Date: 2008-02
• Publisher: Elsevier: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2008 Elsevier
• License: Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1016/j.coi.2007.10.009
• Title of Journal or Parent Work: Current Opinion in Immunology
• ISSN: 0952-7915
• Volume: 20
• Issue: 1
• Start Page: 61
• End Page: 67
• Research Categories: Health Sciences, Pathology; Health Sciences, Immunology

Abstract

For years, DC biologists have oscillated between two seemingly antagonistic ideas: functional specialization (division of labor) of DC subsets and plasticity (multitasking). More recently, a third hypothesis is gathering support: crosstalk between functionally distinct DC subsets. This reveals a previously unappreciated hierarchy of organization within the DC system, and provides a conceptual framework to understand how cooperation between functionally distinct, yet plastic, DC subsets can shape adaptive immunity and immunological memory. Here we review recent advances in this area.