Leveraging ageing models of pulmonary fibrosis: the efficacy of nintedanib in ageing

• Type of Material: Article
• Authors: Kosuke Kato, Emory University; Yoon-Joo Shin, Emory University; Sunny Palumbo, University of Arizona; Ioannis Papageorgiou, Emory University; Seongmin Hahn, University of Arizona; Jodeph D Irish, University of Arizona; Skye P Rounseville, University of Arizona; Robert Krafty, Emory University; Lutz Wollin, Boehringer Ingelheim Pharma GmbH & Co. KG; Maor Sauler, Yale School of Medicine; Louise Hecker, Emory University
• Language: English
• Date: 2021-11-01
• Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD
• Publication Version: Final Published Version
• Copyright Statement: ©The authors 2021.
• License: Creative Commons Attribution-NonCommercial 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1183/13993003.00759-2021
• Title of Journal or Parent Work: EUROPEAN RESPIRATORY JOURNAL
• Volume: 58
• Issue: 5
• Grant/Funding Information: This work was funded by Boehringer Ingelheim Pharma GmbH & Co. KG (L. Hecker). Effort was also supported by the Office of the Assistance Secretary of Defense for Health Affairs through Peer Reviewed Medical Research Program under award number W81XWH-17-1-0443 (L. Hecker); Veterans Administration Health System grant 1 I01 BX003919-01A1 (L. Hecker); and the National Institutes of Health grant 1R21AG054766-01 (L. Hecker). Funding information for this article has been deposited with the Crossref Funder Registry.
• Keywords: Life Sciences & Biomedicine; Science & Technology; SENESCENCE; CELLS; Respiratory System
• Research Categories: Biology, Biostatistics; Health Sciences, Medicine and Surgery

Abstract

Although nintedanib is overwhelmingly prescribed to elderly patients, this is the first study to demonstrate that ageing does not impact the efficacy of nintedanib. This study sheds light on the utility of aged animal models in pulmonary fibrosis. https://bit.ly/3zA9RC5