Role of Substrate and Triggers in the Genesis of Cardiac Alternans, From the Myocyte to the Whole Heart Implications for Therapy

• Type of Material: Article
• Authors: Faisal M Merchant, Emory University; Antonis A. Armoundas, Massachusetts General Hospital
• Language: English
• Date: 2012-01-24
• Publisher: American Heart Association
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2012 American Heart Association, Inc.
• Final Published Version (URL): http://dx.doi.org/10.1161/CIRCULATIONAHA.111.033563
• Title of Journal or Parent Work: Circulation
• ISSN: 0009-7322
• Volume: 125
• Issue: 3
• Start Page: 539
• End Page: 549
• Grant/Funding Information: This work was also supported by a Fellowship and a Science Award from the Center for Integration of Medicine and Innovative Technology (CIMIT); the Deane Institute for Integrative Research in Atrial Fibrillation; and Stroke and the Cardiovascular Research Society.; The work was supported by a Scientist Development Grant (#0635127N); by National Institute of Aging (NIA) grant 1R21AG035128; and NIH grant 1RO1HL103961.
• Keywords: INTRACELLULAR CALCIUM; T-WAVE ALTERNANS; RETICULUM CALCIUM CONTENT; IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR; EFFECTIVE REFRACTORY PERIOD; LONG-QT SYNDROME; RYANODINE RECEPTOR; SARCOPLASMIC-RETICULUM; Peripheral Vascular Disease; ACTION-POTENTIAL ALTERNANS; Life Sciences & Biomedicine; Science & Technology; Cardiac & Cardiovascular Systems; Cardiovascular System & Cardiology; RAT VENTRICULAR MYOCYTES
• Research Categories: Health Sciences, Medicine and Surgery