Consensus nomenclature for the human ArfGAP domain-containing proteins

• Type of Material: Article
• Authors: Richard Kahn, Emory University; Elspeth Bruford, European Bioinformatics Institute; Hiroki Inoue, National Cancer Institute; John M. Logsdon, Jr., University of Iowa; Zhongzhen Nie, Medical College of Georgia; Richard T. Premont, Duke University; Paul A. Randazzo, National Cancer Institute; Masanobu Satake, Tohoku University; Anne B. Theibert, University of Alabama; Maria L. Zapp, University of Massachusetts; Dan Cassel, Technion-Israel Institute of Technology
• Language: English
• Date: 2008-09-22
• Publisher: Rockefeller University Press
• Publication Version: Final Published Version
• Copyright Statement: © 2008, The Rockefeller University Press
• Final Published Version (URL): http://dx.doi.org/10.1083/jcb.200806041
• Title of Journal or Parent Work: Journal of Cell Biology
• ISSN: 0021-9525
• Volume: 182
• Issue: 6
• Start Page: 1039
• End Page: 1044
• Grant/Funding Information: This work was performed with support from extramural grants (GM67226, GM68029, R.A. Kahn; National Institutes of Health GM59989, DA016347, R.T. Premont; AI-043208, M.L. Zapp) and that from the Intramural Program (P.A. Randazzo, H. Inoue) of the National Institutes of Health, Department of Health and Human Services as well as the American Heart Association (0655454U, R.T. Premont), and a grant from the Israel Science Foundation 448/04 (D. Cassel).
• Keywords: Life Sciences & Biomedicine; GTPASE-ACTIVATING PROTEIN; GOLGI; GAP; Science & Technology; MEMBRANE CURVATURE; CLATHRIN; ACTIN CYTOSKELETON; GIT FAMILY; COMPLEX; LOCALIZATION; Cell Biology; REGULATORS
• Research Categories: Health Sciences, Immunology; Chemistry, Biochemistry; Biology, Cell

Abstract

At the FASEB summer research conference on "Arf Family GTPases", held in Il Ciocco, Italy in June, 2007, it became evident to researchers that our understanding of the family of Arf GTPase activating proteins (ArfGAPs) has grown exponentially in recent years. A common nomenclature for these genes and proteins will facilitate discovery of biological functions and possible connections to pathogenesis. Nearly 100 researchers were contacted to generate a consensus nomenclature for human ArfGAPs. This article describes the resulting consensus nomenclature and provides a brief description of each of the 10 subfamilies of 31 human genes encoding proteins containing the Arf-GAP domain.