Consistency of mycobacterium tuberculosis-specific interferon-gamma responses in HIV-1-infected women during pregnancy and postpartum

• Type of Material: Article
• Authors: Sasi R. Jonnalagadda, University of Washington; Elizabeth Brown, University of Washington; Barbara Lohman-Payne, University of Washington; Dalton Wamalwa, University of Nairobi; Carey Farquhar, University of Washington; Kenneth Tapia, University of Washington; Lisa Cranmer, Emory University; Grace C. John-Stewart, University of Washington
• Language: English
• Date: 2012-04-18
• Publisher: Emory University Libraries
• Publication Version: Final Published Version
• Copyright Statement: © 2012 Sasi R. Jonnalagadda et al.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1155/2012/950650
• Title of Journal or Parent Work: Infectious Diseases in Obstetrics and Gynecology
• Volume: 2012
• Start Page: 950650
• End Page: 950650
• Grant/Funding Information: This work is supported by the US National Institutes Health (NIH) through grant no. R21 HD058477-01 and Firland Foundation Grant no. 200910. B. L. Payne and D. Wamalwa were scholars in the International AIDS Training and Research Program, NIH Research Grant D43 TW000007, funded by the Fogarty International Center and the Office of Research on Women's Health. K. Tapia is supported by the University of Washington Center for AIDS Research (CFAR), an NIH-funded program (P30 AI027757), which is supported by the following NIH Institutes and Centers (NIAID, NCI, NIMH, NIDA, NICHD, NHLBI, and NCCAM). G. C. John-Stewart is supported by NIH Research Grant K24 HD054314-04. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the paper.
• Keywords: Mycobacterium tuberculosis; HIV Infections; Pregnancy Complications, Infectious; Interferon-gamma Release Tests; Latent Tuberculosis; Interferon-gamma; Female; Pregnancy; Tuberculosis; Humans; Adult; HIV-1
• Research Categories: Health Sciences, Public Health; Biology, Virology; Health Sciences, Obstetrics and Gynecology

Abstract

Background. We determined the consistency of positive interferon-gamma (IFN-γ) release assays (IGRAs) to detect latent TB infection (LTBI) over one-year postpartum in HIV-1-infected women. Methods. Women with positive IGRAs during pregnancy had four 3-monthly postpartum IGRAs. Postpartum change in magnitude of IFN-γ response was determined using linear mixed models. Results. Among 18 women with positive pregnancy IGRA, 15 (83%) had a subsequent positive IGRA; 9 (50%) were always positive, 3 (17%) were always negative, and 6 (33%) fluctuated between positive and negative IGRAs. Women with pregnancy IGRA IFN-γ 8 spot forming cells (SFCs)/well were more likely to have consistent postpartum IGRA response (odds ratio: 10.0; 95% confidence interval (CI): 0.9-117.0). Change in IFN-γ response over postpartum was 10.2 SFCs/well (95% CI: 1.5-21.8 SFCs/well). Conclusion. Pregnancy positive IGRAs were often maintained postpartum with increased consistency in women with higher baseline responses. There were modest increases in magnitude of IGRA responses postpartum.