Applications of chemogenetics in non-human primates

• Type of Material: Article
• Authors: Jessica Raper, Emory University; Adriana Galvan, Emory University
• Language: English
• Date: 2022-05-25
• Publisher: ELSEVIER SCI LTD
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2022 Elsevier Ltd. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.coph.2022.102204
• Title of Journal or Parent Work: CURRENT OPINION IN PHARMACOLOGY
• Volume: 64
• Start Page: 102204
• End Page: 102204
• Grant/Funding Information: The authors’ research cited in this review was funded by the National Institutes of Health (NINDS 1R21NS106346 (AG), and in part by the National Institutes of Mental Health (NIMH) Autism Center of Excellence Center Grant P50 MH100029and the Office of Research Infrastructure Programs P51 OD011132 (base grant to the Yerkes Research Center).
• Keywords: AAV VECTOR; TOOLS; GENE DELIVERY; DRIVEN; Pharmacology & Pharmacy; INACTIVATION; HAND DEXTERITY; EXPRESSION; PROTEIN; Science & Technology; DREADDS; Life Sciences & Biomedicine

Abstract

Due to its low invasiveness and controllability, chemogenetic approaches offer a highly attractive option to modulate neuronal activity in basic research and future clinical applications. Chemogenetics have revolutionized neuroscience research by facilitating manipulations of selective brain circuits. To date, however, the large majority of these studies have been conducted in rodent models, while the wide application of chemogenetics in nonhuman primates (NHPs) is yet to occur. Still, important progress has been achieved in the use of chemogenetics in NHP studies in the last few years. Here we review the studies that have been published using chemogenetics in NHPs and discuss the current limitations of the technique to its more widespread use in NHPs and possible ways to overcome them.