A Concise Review of the Conflicting Roles of Dopamine-1 versus Dopamine-2 Receptors in Wound Healing

• Type of Material: Article
• Authors: Alexandra R. Vaughn, University of California, Davis; Michael Davis, Emory University; Raja K. Sivamani, University of California, Davis; Roslyn Rivkah Isseroff, University of California, Davis
• Language: English
• Date: 2018-01
• Publisher: MDPI
• Publication Version: Final Published Version
• Copyright Statement: © 2017 by the authors.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.3390/molecules23010050
• Title of Journal or Parent Work: Molecules
• ISSN: 1420-3049
• Volume: 23
• Issue: 1
• Start Page: 50
• End Page: 50
• Grant/Funding Information: No funding was received for this article.
• Keywords: wound healing; dopamine; wounds
• Research Categories: Health Sciences, General; Health Sciences, Medicine and Surgery

Abstract

Catecholamines play an important regulatory role in cutaneous wound healing. The exact role of dopamine in human epidermis has yet to be fully elucidated. Current published evidence describes its differential effects on two separate families of G protein coupled receptors: D1-like and D2-like dopamine receptors. Dopamine may enhance angiogenesis and wound healing through its action on dopamine D1 receptors, while impairing wound healing when activating D2 receptors. This review summarizes the evidence for the role of dopamine in wound healing and describes potential mechanisms behind its action on D1 versus D2-like receptors in the skin.