Decreased expression of acetaminophen-metabolizing enzymes and glutathione in asthmatic children after acetaminophen exposure

• Type of Material: Article
• Authors: Susan T. Stephenson, Emory University; Graham Hadley, Emory University; Lou Ann Brown, Emory University; Anne M Fitzpatrick, Emory University
• Language: English
• Date: 2012-03
• Publisher: Elsevier: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2011 American Academy of Allergy, Asthma and Immunology. Published by Mosby, Inc. All rights reserved.
• License: Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1016/j.jaci.2011.10.021
• Title of Journal or Parent Work: Journal of Allergy and Clinical Immunology: In Practice
• ISSN: 2213-2201
• Volume: 129
• Issue: 3
• Start Page: 867
• End Page: 869
• Grant/Funding Information: This work was funded by RO1 NR012021 and was supported in part by PHS grants UL1 RR025008 from the Clinical and Translational Science Award Program, National Institutes of Health, National Center for Research Resources
• Keywords: children; drug metabolism; acetaminophen; glutathione; cytochrome p450; glutathione-S-transferases; Asthma; oxidative stress
• Research Categories: Health Sciences, Immunology

Abstract

Summary Children with moderate-to-severe asthma have decreased expression of acetaminophen metabolizing genes and glutathione that may account for the previously-reported risk of acetaminophen in this vulnerable population.