Publication

Thy-1 (CD90)-regulated cell adhesion and migration of mesenchymal cells: insights into adhesomes, mechanical forces, and signaling pathways

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Last modified
  • 06/25/2025
Type of Material
Authors
    Alejandra Valdivia, Emory UniversityAna María Avalos, Universidad Autónoma de ChileLisette Leyton, Universidad de Chile
Language
  • English
Date
  • 2023-11-30
Publisher
  • Frontiers
Publication Version
Copyright Statement
  • © 2023 Valdivia, Avalos and Leyton.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 11
Start Page
  • 1221306
Grant/Funding Information
  • LL was supported by Fondo Nacional de Desarrollo Científico y Tecnológico #1200836 and Agencia Nacional de Investigación y Desarrollo (ANID)-FONDAP #15130011.
Abstract
  • Cell adhesion and migration depend on the assembly and disassembly of adhesive structures known as focal adhesions. Cells adhere to the extracellular matrix (ECM) and form these structures via receptors, such as integrins and syndecans, which initiate signal transduction pathways that bridge the ECM to the cytoskeleton, thus governing adhesion and migration processes. Integrins bind to the ECM and soluble or cell surface ligands to form integrin adhesion complexes (IAC), whose composition depends on the cellular context and cell type. Proteomic analyses of these IACs led to the curation of the term adhesome, which is a complex molecular network containing hundreds of proteins involved in signaling, adhesion, and cell movement. One of the hallmarks of these IACs is to sense mechanical cues that arise due to ECM rigidity, as well as the tension exerted by cell-cell interactions, and transduce this force by modifying the actin cytoskeleton to regulate cell migration. Among the integrin/syndecan cell surface ligands, we have described Thy-1 (CD90), a GPI-anchored protein that possesses binding domains for each of these receptors and, upon engaging them, stimulates cell adhesion and migration. In this review, we examine what is currently known about adhesomes, revise how mechanical forces have changed our view on the regulation of cell migration, and, in this context, discuss how we have contributed to the understanding of signaling mechanisms that control cell adhesion and migration.
Author Notes
Keywords
Research Categories
  • Biology, General
  • Biology, Cell

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