Urinary tract infection in the setting of vesicoureteral reflux.

• Type of Material: Article
• Authors: Andrew Kirsch, Emory University; Michael L. Garcia-Roig, Emory University
• Language: English
• Date: 2016-06-30
• Publisher: F1000Research
• Publication Version: Final Published Version
• Copyright Statement: © 2016 Garcia-Roig ML and Kirsch AJ.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.12688/f1000research.8390.1
• Title of Journal or Parent Work: F1000Research
• ISSN: 2046-1402
• Volume: 5
• Start Page: 1552
• End Page: 1552
• Keywords: Vesicoureteral reflux; pyelonephritis; pediatric urology; urinary tract infections
• Research Categories: Health Sciences, General; Health Sciences, Pathology

Abstract

Vesicoureteral reflux (VUR) is the most common underlying etiology responsible for febrile urinary tract infections (UTIs) or pyelonephritis in children. Along with the morbidity of pyelonephritis, long-term sequelae of recurrent renal infections include renal scarring, proteinuria, and hypertension. Treatment is directed toward the prevention of recurrent infection through use of continuous antibiotic prophylaxis during a period of observation for spontaneous resolution or by surgical correction. In children, bowel and bladder dysfunction (BBD) plays a significant role in the occurrence of UTI and the rate of VUR resolution. Effective treatment of BBD leads to higher rates of spontaneous resolution and decreased risk of UTI.