Homeostasis disrupted by strain mechanosensing

• Type of Material: Article
• Authors: Tyler J. DiStefano, Icahn School of Medicine at Mount Sinai, New York; Svenja Illien-Junger, Emory University; James C. Iatridis, Icahn School of Medicine at Mount Sinai, New York
• Language: English
• Date: 2019-12-01
• Publisher: Nature Publishing Group
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2019 Springer Nature Limited.
• Final Published Version (URL): http://dx.doi.org/10.1038/s41551-019-0491-3
• Title of Journal or Parent Work: NATURE: Biomedical Engineering
• Volume: 3
• Issue: 12
• Start Page: 951
• End Page: 952
• Grant/Funding Information: None declared
• Keywords: Intervertebral disc degeneration; Extracellular matrix; Engineering; Technology; Engineering, Biomedical; Science & Technology; Residual strains
• Research Categories: Biology, Cell; Engineering, Biomedical; Biophysics, Medical

Abstract

In injured intervertebral discs, disruptions in fibre organization and in cellular contractility result in a fibrotic phenotype and progressive tissue degeneration.